5. I Am Alive (game site)
All the other games on this list have gained some sort of cult following and are widely respected by the independent gaming community. I Am Alive, though, is underrappreciated by just about everyone. The game was in development at Ubisoft for nearly nine years, and although it gained attention with the glimpses shown during production, by the time it finally released on Xbox Live Arcade in March, it was completely overlooked. Although it's a downloadable title, you can tell I Am Alive had ambitions beyond what it could ever actually achieve.
It's a survival game in the truest sense of the word--you play as a man searching for his family in post-apocalyptic American city. He's not a typical superhuman game protagonist; he can climb abandoned buildings, but can only hold his weight for a certain amount of time before he wears out. He finds a gun, but he typically never has more than one bullet. As a result, the player is forced to bluff their way through hostile situations, threatening enemies with a gun that they know is empty. While most games today are about empowerment, I Am Alive is about weakness. I wish we could see more small games from major publishers like this in the future.

